{"product_id":"p16-ink4a-rabbit-pab-a23882","title":"p16 INK4A Rabbit pAb - A23882","description":"p16 INK4A Rabbit pAb\n\nSizes: 20μL, 100μL\n\nCatalogue Numbers: A23882-20, A23882-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: Enables MDM2\/MDM4 family protein binding activity; enzyme inhibitor activity; and protein N-terminus binding activity. Involved in several processes, including negative regulation of lymphocyte proliferation; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including negative regulation of cellular protein metabolic process; negative regulation of mammary gland epithelial cell proliferation; and positive regulation of apoptotic process involved in mammary gland involution. Located in cytoplasm and granular component. Part of protein-containing complex. Is expressed in several structures, including bone marrow; central nervous system; dorsal root ganglion; eye; and testis. Human ortholog (s) of this gene implicated in several diseases, including breast cancer (multiple) ; carcinoma (multiple) ; hematologic cancer (multiple) ; melanoma (multiple) ; and nervous system cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A).\n\nCategory: Polyclonal Antibodies\n\nApplications: WB, ELISA\n\nCross-reactivity: Human, Mouse, Rat\n\nProtein Weight: 17KDa\n\nObserved Molecular Weight: 14kDa\n\nImmunogen: Recombinant protein (or fragment)\n\nSpecies: Mouse\n\nGeneID: 12578\n\nSWISS: P51480\n\nAlternate Names: Arf; p16; MTS1; Pctr1; p19ARF; p16INK4a; p19\u003carf\u003e; ARF-INK4a; INK4a-ARF; Ink4a\/Arf; p16 (INK4a) ; p16 INK4A\n\nSource: Rabbit\n\nIsotype: IgG\n\nPurity: Affinity purification\n\nStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.\n\nRecommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\n\nNCBI Alias: Cdkn2a\n\nResearch Use Only\u003c\/arf\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189407473843,"sku":"A23882-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189407506611,"sku":"A23882-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_3458cd97-4a51-4eb7-871c-f6e252c37c6c.png?v=1766426495","url":"https:\/\/afsbio.com\/products\/p16-ink4a-rabbit-pab-a23882","provider":"AFSBio Inc.","version":"1.0","type":"link"}