{"product_id":"p52-s6-kinase-rabbit-pab-es5514","title":"p52 S6 kinase rabbit pAb - ES5514","description":"\u003cp\u003ep52 S6 kinase rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES5514-50, ES5514-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:ATP + a protein = ADP + a phosphoprotein., caution:Instead of Lys-820, Arg-820 is found at the binding site., domain:The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site., function:May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell., similarity:Belongs to the protein kinase superfamily. Ser\/Thr protein kinase family. S6 kinase subfamily., similarity:Contains 1 MIT domain., similarity:Contains 1 PX (phox homology) domain., similarity:Contains 2 protein kinase domains., subcellular location:Also found in some small dot-like or ring-shaped early endosome structures., subunit:Interacts with SPHK1 and phosphatidylinositol 3-phosphate., tissue specificity:Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: RPS6KC1; RPK118; Ribosomal protein S6 kinase delta-1; S6K-delta-1; 52 kDa ribosomal protein S6 kinase; Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein; SPHK1-binding protein\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human RPS6KC1. AA range:231-280\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 117kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 26750\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q96S38\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm. Membrane. Early endosome.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202251251891,"sku":"ES5514-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202251284659,"sku":"ES5514-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_0e0de64a-60cf-4e07-b38f-ebb816f3f827.png?v=1767125146","url":"https:\/\/afsbio.com\/products\/p52-s6-kinase-rabbit-pab-es5514","provider":"AFSBio Inc.","version":"1.0","type":"link"}