{"product_id":"p53-dinp1-polyclonal-antibody-e-ab-92850","title":"p53 DINP1 Polyclonal Antibody - E-AB-92850","description":"\u003cp\u003ep53 DINP1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-92850-60, E-AB-92850-120, E-AB-92850-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: p53 DINP1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: TP53INP1; SIP; TP53DINP1; TP53INP1A; TP53INP1B; Teap; p53DINP1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q96A56\u003c\/p\u003e\n\n\u003cp\u003eBackground: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1\/L2, MAP1LC3A\/B\/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53\/TP53-driven oxidative stress response. Possesses both a p53\/TP53-independent intracellular reactive oxygen species (ROS regulatory function and a p53\/TP53-dependent transcription regulatory function. Positively regulates p53\/TP53 and p73\/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53\/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human p53 DINP1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 18kDa\/27kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 32kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146660577459,"sku":"E-AB-92850-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146660610227,"sku":"E-AB-92850-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146660642995,"sku":"E-AB-92850-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8f609242-3f25-4723-9a31-dc8def42b41a.png?v=1710299602","url":"https:\/\/afsbio.com\/products\/p53-dinp1-polyclonal-antibody-e-ab-92850","provider":"AFSBio Inc.","version":"1.0","type":"link"}