{"product_id":"p70-s6-kinase-β-phospho-ser423-rabbit-polyclonal-antibody-es7097","title":"p70 S6 kinase β (phospho Ser423) Rabbit Polyclonal Antibody - ES7097","description":"\u003cp\u003ep70 S6 kinase β (phospho Ser423) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES7097-50, ES7097-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: ribosomal protein S6 kinase B2(RPS6KB2) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine\/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: RPS6KB2, STK14B, Ribosomal protein S6 kinase beta-2, S6K-beta-2, S6K2, 70 kDa ribosomal protein S6 kinase 2, P70S6K2, p70-S6K 2, S6 kinase-related kinase, SRK, Serine\/threonine-protein kinase 14B, p70 ribosomal S6 kinase beta, S6K-beta, p70\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human p70 S6 Kinase beta around the phosphorylation site of Ser423. AA range:389-438\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: P70S6k\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Phospho-p70 S6 kinase β (S423) Polyclonal Antibody detects endogenous levels of p70 S6 kinase β protein only when phosphorylated at S423.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/5000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Brain, Epithelium, Lymph,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 53kD\u003c\/p\u003e\n\n\u003cp\u003eFields: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 signaling pathway, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, TGF-beta signaling pathway, Apelin signaling pathway, Fc gamma R-mediated phagocytosis, Thermogenesis, Insulin signaling pathway, Insulin resistance, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein\u003cbr\u003e\nFunction: Phosphorylates specifically ribosomal protein S6\u003cbr\u003e\nPTM: Phosphorylated upon DNA damage, probably by ATM or ATR\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily. AGC Ser\/Thr protein kinase family. S6 kinase subfamily\u003cbr\u003e\nSimilarity: Contains 1 AGC-kinase C-terminal domain\u003cbr\u003e\nSimilarity: Contains 1 protein kinase domain\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cytoplasm Nucleus\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: RPS6KB2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Ribosomal protein S6 kinase beta-2\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 58988\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9Z1M4\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313689710771,"sku":"ES7097-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313689743539,"sku":"ES7097-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/p70-s6-kinase-%ce%b2-phospho-ser423-rabbit-polyclonal-antibody-es7097","provider":"AFSBio Inc.","version":"1.0","type":"link"}