{"product_id":"pa26-polyclonal-antibody-bt-ap06869","title":"PA26 Polyclonal Antibody - BT-AP06869","description":"\u003cp\u003ePA26 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP06869-20, BT-AP06869-50, BT-AP06869-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: SESN1 encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The sestrin 1 mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SESN1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PA26 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 56557\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9Y6P5; Mouse: P58006\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SESN1; PA26; SEST1; Sestrin-1; p53-regulated protein PA26\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 27244; Mouse: 140742\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239809245363,"sku":"BT-AP06869-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239809278131,"sku":"BT-AP06869-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239809310899,"sku":"BT-AP06869-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_9b5fc59c-8f58-4cf9-a85d-05b661fad915.png?v=1769399470","url":"https:\/\/afsbio.com\/products\/pa26-polyclonal-antibody-bt-ap06869","provider":"AFSBio Inc.","version":"1.0","type":"link"}