{"product_id":"pacs1-polyclonal-antibody-bt-ap12729","title":"PACS1 Polyclonal Antibody - BT-AP12729","description":"\u003cp\u003ePACS1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP12729-20, BT-AP12729-50, BT-AP12729-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the proteaseandapos;s phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Metabolism; Microbiology; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PACS1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Phosphofurin acidic cluster sorting protein 1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q6VY07; Mouse: Q8K212; Rat: O88588\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Phosphofurin acidic cluster sorting protein 1;PACS-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 55690\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239276503219,"sku":"BT-AP12729-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239276535987,"sku":"BT-AP12729-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239276568755,"sku":"BT-AP12729-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_80cf619f-e0e1-40fb-be9f-7748cfd57c9c.png?v=1769392401","url":"https:\/\/afsbio.com\/products\/pacs1-polyclonal-antibody-bt-ap12729","provider":"AFSBio Inc.","version":"1.0","type":"link"}