{"product_id":"paf-r-polyclonal-antibody-bt-ap06881","title":"PAF-R Polyclonal Antibody - BT-AP06881","description":"\u003cp\u003ePAF-R Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP06881-20, BT-AP06881-50, BT-AP06881-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: PTAFR (platelet activating factor receptor) encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and\/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PTAFR\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PAF-R Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 39203\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P25105; Mouse: Q62035; Rat: P46002\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PTAFR; PAFR; Platelet-activating factor receptor; PAF-R; PAFr\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5724; Mouse: 19204; Rat: 58949\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239810195635,"sku":"BT-AP06881-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239810228403,"sku":"BT-AP06881-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239810261171,"sku":"BT-AP06881-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_efb3b3bd-7bd9-4eec-94f6-e12af83f91d6.png?v=1769399476","url":"https:\/\/afsbio.com\/products\/paf-r-polyclonal-antibody-bt-ap06881","provider":"AFSBio Inc.","version":"1.0","type":"link"}