{"product_id":"pank2-polyclonal-antibody-bt-ap12768","title":"PANK2 Polyclonal Antibody - BT-AP12768","description":"\u003cp\u003ePANK2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP12768-20, BT-AP12768-50, BT-AP12768-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Metabolism; Neuroscience; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PANK2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Pantothenate kinase 2, mitochondrial\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9BZ23\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Pantothenate kinase 2, mitochondrial;hPanK2;EC 2.7.1.33;Pantothenic acid kinase 2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 80025\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239277256883,"sku":"BT-AP12768-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239277289651,"sku":"BT-AP12768-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239277322419,"sku":"BT-AP12768-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_72a5be40-0557-4f83-8cf8-9bbd3dc49bce.png?v=1769392410","url":"https:\/\/afsbio.com\/products\/pank2-polyclonal-antibody-bt-ap12768","provider":"AFSBio Inc.","version":"1.0","type":"link"}