{"product_id":"paox-polyclonal-antibody-ra28509","title":"PAOX Polyclonal Antibody - RA28509","description":"\u003cp\u003ePAOX Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA28509-50, RA28509-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:N (1),N (12) -diacetylspermine + O (2) + H (2) O = N (1) -acetylspermidine + 3-acetamidobutanal + H (2) O (2) .,catalytic activity:N (1) -acetylspermidine + O (2) + H (2) O = putrescine + 3-acetamidopropanal + H (2) O (2) .,catalytic activity:N (1) -acetylspermine + O (2) + H (2) O = spermidine + 3-acetamidopropanal + H (2) O (2) .,cofactor:Binds 1 FAD per subunit.,function:Flavoenzyme which catalyzes the oxidation of N (1) -acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N (1) -acetylspermidine to putrescine. Substrate specificity: N (1) -acetylspermine = N (1) -acetylspermidine \u0026gt; N (1),N (12) -diacylspermine \u0026gt;\u0026gt; spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.,induction:By polyamine analogs.,miscellaneous:Oxidizes N (1) -acetylated polyamines on the exo-side of their N (4) -amino groups. Plant PAO oxidizes spermine on the endo-side of the N (4) -nitrogen.,pathway:Amine and polyamine metabolism; spermine metabolism.,similarity:Belongs to the flavin monoamine oxidase family.,subunit:Monomer.,tissue specificity:Widely expressed. Not detected in spleen. Expressed at lower level in neoplastic tissues.,\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Western Blot: 1\/500 - 1\/2000. IHC-p: 1:100-300 ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: PAOX; PAO; Peroxisomal N (1) -acetyl-spermine\/spermidine oxidase; Polyamine oxidase\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC-p; IF (paraffin section) ; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Rat; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 196743\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 70\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q6QHF9\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45122350776499,"sku":"RA28509-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45122350809267,"sku":"RA28509-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c669e432-392e-4d52-b471-739e7f2dbbf5.png?v=1773347891","url":"https:\/\/afsbio.com\/products\/paox-polyclonal-antibody-ra28509","provider":"AFSBio Inc.","version":"1.0","type":"link"}