{"product_id":"par2-rabbit-polyclonal-antibody-es11627","title":"PAR2 Rabbit Polyclonal Antibody - ES11627","description":"\u003cp\u003ePAR2 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES11627-50, ES11627-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human protein. at AA range: 10-90\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: PAR2\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PAR2 Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon (PubMed:7556175, PubMed:8615752), Moderate expression is detected in many organs, but none in brain or skeletal muscle (PubMed:7556175, PubMed:8615752), Expressed in endothelial cells (PubMed:23202369),\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 43kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels, African trypanosomiasis\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Receptor for trypsin and trypsin-like enzymes coupled to G proteins that stimulate phosphoinositide hydrolysis. May have a role in the regulation of vascular tone\u003cbr\u003e\nOnline Information: Protease-activated receptor entry,PTM: A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand\u003cbr\u003e\nSimilarity: Belongs to the G-protein coupled receptor 1 family\u003cbr\u003e\nTissue Specificity: Widely expressed in tissues with especially high levels in pancreas, liver, kidney, small intestine, and colon. Moderate expression is detected in many organs, but none in brain or skeletal muscle\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cell membrane, Multi-pass membrane protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: F2RL1 GPR11 PAR2\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cle\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P55086\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q63645\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314506649779,"sku":"ES11627-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314506682547,"sku":"ES11627-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/par2-rabbit-polyclonal-antibody-es11627","provider":"AFSBio Inc.","version":"1.0","type":"link"}