{"product_id":"park7-dj1-polyclonal-antibody-bs91015","title":"PARK7\/DJ1 Polyclonal Antibody-BS91015","description":"\u003cp\u003ePARK7\/DJ1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91015-50, BS91015-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q99497(Human) Q99LX0(Mouse) O88767(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC\/IF, IHC, IP, , FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000-1:2,000\u003cbr\u003e\nICC:1:100-1:500\u003cbr\u003e\nIHC:1:100-1:500\u003cbr\u003e\nFC:1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eBackground: PARK7\/DJ1 is a ubiquitously expressed protein involved in various cellular processes including cell proliferation, RNA-binding, and oxidative stress. The protein has been found to colocalize within a subset of pathologic tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Defects in PARK7\/DJ1 are the cause of autosomal recessive early-onset Parkinson's disease 7 (PARK7). Parkinson's disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. The disease is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK7 is characterized by onset before 40 years and slow progression. It has also been suggested that PARK7\/DJ1 is a mitogen dependent oncogene product involved in Ras related signal transduction pathways.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PARK7\/DJ1 polyclonal antibody detects endogenous levels of PARK7\/DJ1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 20 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of PARK7 on different lysates using anti-PARK7 antibody at 1\/1,000 dilution. \u003cbr\u003e\n Positive control: \u003cbr\u003e\n Lane 1: Hela \u003cbr\u003e\n Lane 2: Jurkat \u003cbr\u003e\n Lane 3: NIH\/3T3, ICC staining PARK7 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: DJ-1, PARK7, CAP1, DJ-1, DJ1, DJ1 protein, Epididymis secretory sperm binding protein Li 67p, FLJ27376, FLJ34360, FLJ92274, HEL S 67p, Oncogene DJ1, OTTHUMP00000001348, OTTHUMP00000001349, OTTHUMP00000001350, OTTHUMP00000001351, PARK7, PARK7, Parkinson disease (autosomal recessive, early onset) 7, Parkinson disease protein 7, Parkinson protein 7, Protein DJ-1, SP22,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42984607416499,"sku":"BS91015-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42984607449267,"sku":"BS91015-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_7c8ebf53-ca34-4456-89b0-4fdec7763d8b.jpg?v=1705919249","url":"https:\/\/afsbio.com\/products\/park7-dj1-polyclonal-antibody-bs91015","provider":"AFSBio Inc.","version":"1.0","type":"link"}