{"product_id":"pax6-polyclonal-antibody-bs91023","title":"PAX6 Polyclonal Antibody-BS91023","description":"\u003cp\u003ePAX6 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91023-50, BS91023-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P26367(Human) P63015(Mouse) P63016(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000-1:5,000\u003cbr\u003e\nFC:1:50-1:100\u003cbr\u003e\nIHC:1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Pax genes contain paired domains with strong homology to genes in Drosophila which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PAX6 polyclonal antibody detects endogenous levels of PAX6 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 47 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of PAX6 on mouse eyes lysates using anti-PAX6 antibody at 1\/1,000 dilution., Immunohistochemical analysis of paraffin-embedded rat eyes tissue using anti-PAX6 antibody. Counter stained with hematoxylin.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: PAX6, AN 2, AN, AN2, Aniridia type II protein, D11S812E, FVH1, KIAA0552, Leucine zipper putative tumor suppressor 3, LZTS3, MGC17209, MGDA, Oculorhombin, Paired box 6, Paired box gene 6 (aniridia keratitis), Paired Box Gene 6, Paired box homeotic gene 6, Paired box protein Pax-6, Paired box protein Pax6, PAX 6, PAX6, PAX6, ProSAP-interacting protein 1, PROSAPIP1, Sey, WAGR,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42984607809715,"sku":"BS91023-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42984607842483,"sku":"BS91023-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_e7983aeb-1047-45c1-b79c-99823c78d3af.jpg?v=1705919258","url":"https:\/\/afsbio.com\/products\/pax6-polyclonal-antibody-bs91023","provider":"AFSBio Inc.","version":"1.0","type":"link"}