{"product_id":"pax7-rabbit-polyclonal-antibody-es10905","title":"PAX7 Rabbit Polyclonal Antibody - ES10905","description":"\u003cp\u003ePAX7 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES10905-50, ES10905-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: approximately 7-10 business days, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008],\u003c\/p\u003e \n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: PAX7,\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: PAX7 Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e \n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 57kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Transcriptional misregulation in cancer\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: A chromosomal aberration involving PAX7 is a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation t(1;13)(p36;q14) with FOXO1. The resulting protein is a transcriptional activator. Probable transcription factor. May have a role in myogenesis. Similarity: Belongs to the paired homeobox family. Similarity: Contains 1 homeobox DNA-binding domain. Similarity: Contains 1 paired domain. Subunit: Can bind to DNA as a heterodimer with PAX3. Interacts with DAXX.\u003c\/p\u003e \n\n\u003cp\u003eSubcellular Location: Nucleus\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: PAX7, HUP1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Paired box protein Pax-7, HuP1\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 5081\u003c\/p\u003e\n\n\u003cp\u003eHuman SwissProt Number: P23759\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P47239\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":45825495564467,"sku":"ES10905-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45825495597235,"sku":"ES10905-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk-biotechnology-logo-product.jpg?v=1786476023","url":"https:\/\/afsbio.com\/products\/pax7-rabbit-polyclonal-antibody-es10905","provider":"AFSBio Inc.","version":"1.0","type":"link"}