{"product_id":"pax8-polyclonal-antibody-bs3459","title":"PAX8 Polyclonal Antibody-BS3459","description":"\u003cp\u003ePAX8 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS3459-50, BS3459-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q06710\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Paired box (PAX) proteins are a family of transcription factors that play important and diverse roles in animal development . Nine PAX proteins (PAX1-9) have been described in humans and other mammals. They are defined by the presence of an amino-terminal \"paired\" domain, consisting of two helix-turn-helix motifs, with DNA binding activity. PAX proteins are classified into four structurally distinct subgroups (I-IV) based on the absence or presence of a carboxy-terminal homeodomain and a central octapeptide region. Subgroup I (PAX1 and 9) contains the octapeptide but lacks the homeodomain; subgroup II (PAX2, 5, and 8) contains the octapeptide and a truncated homeodomain; subgroup III (PAX3 and 7) contains the octapeptide and a complete homeodomain; and subgroup IV (PAX4 and 6) contains a complete homeodomain but lacks the octapeptide region. PAX proteins play critically important roles in development by regulating transcriptional networks responsible for embryonic patterning and organogenesis; a subset of PAX proteins also maintain functional importance during postnatal development . Research studies have implicated genetic mutations that result in aberrant expression of PAX genes in a number of cancer subtypes, with members of subgroups II and III identified as potential mediators of tumor progression.\u003c\/p\u003e\n\n\u003cp\u003ePAX8 is involved in the development of thyroid follicular cells and the expression of thyroid-specific genes (5). Investigators have associated mutations in the PAX8 gene with thyroid dysgenesis, thyroid follicular carcinomas, and atypical follicular thyroid adenomas (6,7).\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PAX8 polyclonal antibody detects endogenous levels of PAX8 protein.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of PXN polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane1:A2780 whole cell lysate(40ug)\u003cbr\u003e\nLane2:MCF-7 whole cell lysate(40ug)\u003cbr\u003e\nLane3:HEK293T whole cell lysate(40ug)\u003cbr\u003e\nLane4:HUT78 whole cell lysate(40ug)\u003cbr\u003e\nLane5:SK-OVCAR3 whole cell lysate(40ug)\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 43 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; \u003cbr\u003e\nbHLHe39; MYC;\u003c\/p\u003e \n\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to Human PAX8.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42910465130675,"sku":"BS3459-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42910465163443,"sku":"BS3459-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_36728921-5057-45aa-8c4c-01d6b0ad5227.jpg?v=1703092919","url":"https:\/\/afsbio.com\/products\/pax8-polyclonal-antibody-bs3459","provider":"AFSBio Inc.","version":"1.0","type":"link"}