{"product_id":"pbf-r151-polyclonal-antibody-bs2285","title":"PBF (R151) Polyclonal Antibody-BS2285","description":"\u003cp\u003ePBF (R151) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS2285-50, BS2285-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P53801\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eBackground: PBF, also known as PTTG1IP (pituitary tumor-transforming 1 interacting protein), is a 180 amino acid single-pass type I membrane protein that localizes both the cytoplasm and the nucleus and contains a coiled-coil domain. Expressed ubiquitously, PBF interacts with PTTG and is thought to facilitate the nuclear translocation of PTTG, thereby allowing the PTTG-dependent transcriptional activation of fibroblast growth factor (FGF). The gene encoding PBF maps to human chromosome 21, which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer’s disease, amyotrophic lateral sclerosis and, most notably, Down syndrome (also known as trisomy 21).\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PBF (R151) polyclonal antibody detects endogenous levels of PBF protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of PBF (R151) pAb at 1:500 dilution\u003cbr\u003e\nLane 1: Panc1 whole cell lysate (40ug)\u003cbr\u003e\nLane 2: SGC7901 whole cell lysate (40ug)\u003cbr\u003e\nLane 3: A375 whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of PBF (R151) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 22 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: PTTG binding factor; PTTG-binding factor; PTTG; Pttg1ip; PBF; PTTG1IP\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 130-180 of Human PBF.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42953222488243,"sku":"BS2285-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42953222521011,"sku":"BS2285-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_885f0abb-f388-444b-9231-a0560c23ba1c.jpg?v=1705057082","url":"https:\/\/afsbio.com\/products\/pbf-r151-polyclonal-antibody-bs2285","provider":"AFSBio Inc.","version":"1.0","type":"link"}