{"product_id":"pcbp2-polyclonal-antibody-e-ab-60713","title":"PCBP2 Polyclonal Antibody - E-AB-60713","description":"\u003cp\u003ePCBP2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-60713-60, E-AB-60713-120, E-AB-60713-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PCBP2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: PCBP2; HNRNPE2; HNRPE2; hnRNP-E2\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Epigenetics and Nuclear Signaling, Microbiology\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q15366\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human PCBP2 (NP_001122383.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000   IHC \t1:50-1:200   IF \t1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 33kDa\/34kDa\/35kDa\/38kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 39kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146104504499,"sku":"E-AB-60713-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146104537267,"sku":"E-AB-60713-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146104570035,"sku":"E-AB-60713-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d44a0ca2-7289-44a0-807f-79ef507bb9e7.png?v=1710290926","url":"https:\/\/afsbio.com\/products\/pcbp2-polyclonal-antibody-e-ab-60713","provider":"AFSBio Inc.","version":"1.0","type":"link"}