PCNA - 0.2mg

PCNA - 0.2mg

Regular price
$724.90
Regular price
Sale price
$724.90
Unit price
per 
Availability
Sold out

Proliferating cell nuclear antigen
Cyclin

Uniprot ID:  P12004
mRNA RefSeq:  NM_182649 NM_002592
Protein RefSeq:  NP_002583 NP_872590
Size: 0.2mg
Source: Recombinant
Catalogue Number: ATP03-02

Product Information

Anti-PCNA antibodies were initially believed to be specific for SLE, but they have now been described in patients with Sjögren's syndrome as well as in a range of other clinical conditions such as hepatitis B, hepatitis C, and malignant disease. Anti-PCNA antibodies in patients with SLE have been reported to correlate with a greater incidence of glomerulonephritis. PCNA is a member of the DNA sliding clamp (ß clamp) family and has an essential role in DNA synthesis. The protein exists as a homotrimer and acts by encircling DNA to serve as a scaffold on which DNA polymerases are tethered. PCNA is also known to interact with a number of other proteins that are involved in DNA replication, repair or methylation or in cell cycle regulation. PCNA deletion mutant studies suggest that autoantibodies in SLE sera are very heterogeneous and can react with a range of different epitopes, whereas autoantibodies present in patients with hepatitis B recognise preferentially the C-terminal of PCNA. Sulfhydryl groups present in PCNA also appear to be essential for autoantibody binding.
 

PDF-logo-dl PCNA datasheet

Clinical Indications

Systemic Lupus Erythematosus
Sjögren's Syndrome

MSDS

PDF-logo-dl  Material Safety Data Sheet

References

Miyachi, K. et al. (1978) J. Immunol. 121, 2228

Takasaki, Y. et al. (1984) J. Exp. Med. 159, 981

Tan, E.M. (1989) Adv. Immunol. 44, 93

Yeo, J.P. & Toh, B.H. (1994) Autoimmunity 18, 291

Mahler, M. et al. (2012) Autoimmunity Rev. 11, 771

Mahler, M. et al. (2010) Lupus 19, 1527

Tzang, B.-S.et al. (1999) Ann. Rheum. Dis. 58, 630

Hsu, T.C. et al. (2006) Clin. Exp. Immunol. 144, 110

Takahashi, T. et al. (1997) Leuk. Lymphoma 28, 113

Vermeersch, P. et al. (2009) Ann. Rheum. Dis. 68, 1791

Fritzler, M.J. et al. (1983) Arthritis Rheum. 26, 140

Moldovan, G.-L. et al. (2007) Cell 129, 665

Brand, S.R. et al. (1994) J. Immunol. 153, 3070

Krishna, T.S. et al. (1994) J. Mol. Biol. 241, 265

Maga, G. & Huebscher, U. (2003) J. Cell Sci. 116, 3051

Huff, J.P. et al. (1990) J. Exp. Med. 172, 419

Tasi, W.-M. et al. (1992) J. Immunol. 149, 2227