{"product_id":"pcsk9-rabbit-pab-a24478","title":"PCSK9 Rabbit pAb - A24478","description":"\u003cp\u003ePCSK9 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A24478-20, A24478-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF\/ICC, IP, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 20kDa\/74kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 65kDa\/80kDa\/65kDa, 80kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment) .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 255738\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q8NBP7\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: PCSK9; FH3; HCHOLA3; LDLCQ1; NARC-1; NARC1; PC9; proprotein convertase subtilisin\/kexin type 9\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:1000 IF\/ICC, 1:50 - 1:200 IP, 0.5μg-4μg antibody for 200μg-400μg extracts of whole cells ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics \u0026amp; Nuclear Signaling, RNA Binding, Cancer, Signal Transduction, Cell Biology \u0026amp; Developmental Biology, Apoptosis, Ubiquitin, Endocrine \u0026amp; Metabolism, Amino acid metabolism, Lipid Metabolism, Cholesterol Metabolism, Stem Cells, Neural Stem Cells, Cardiovascular, Lipids.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: PCSK9\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189851054259,"sku":"A24478-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189851087027,"sku":"A24478-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_1cb33488-1f24-470f-a97e-e444e8337592.png?v=1766436762","url":"https:\/\/afsbio.com\/products\/pcsk9-rabbit-pab-a24478","provider":"AFSBio Inc.","version":"1.0","type":"link"}