{"product_id":"pd-1-cd279-polyclonal-antibody-e-ab-70311","title":"PD-1\/CD279 Polyclonal Antibody - E-AB-70311","description":"\u003cp\u003ePD-1\/CD279 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-70311-60, E-AB-70311-120, E-AB-70311-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PD-1\/CD279\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CD279; CD279 antigen; hPD 1; hPD l; hPD-1; hSLE1; PD 1; PD-1; PD1; PDCD 1; PDCD1; PDCD1; Programmed cell death 1; Programmed cell death 1 protein; Programmed cell death protein 1; Protein PD 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Immunology\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q15116,Q02242\u003c\/p\u003e\n\n\u003cp\u003eBackground: Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28\/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) . PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines . Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function . It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity . The calculated molecular weight of PD-1 is 32 kDa. It has been reported that PD-1 is heavily glycosylated and migrates with an apparent molecular mass of 47-55 kDa on SDS-PAGE .\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.75 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH conjugated Synthetic peptide corresponding to Mouse PD-1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 32kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 47-55kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146518724787,"sku":"E-AB-70311-60","price":224.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146518757555,"sku":"E-AB-70311-120","price":364.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146518790323,"sku":"E-AB-70311-200","price":574.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_a07d5f2c-194d-4011-8997-c40302abce18.png?v=1710296771","url":"https:\/\/afsbio.com\/products\/pd-1-cd279-polyclonal-antibody-e-ab-70311","provider":"AFSBio Inc.","version":"1.0","type":"link"}