{"product_id":"pd-1-cd279-rabbit-pab-a11973","title":"PD-1\/CD279 Rabbit pAb - A11973","description":"\u003cp\u003ePD-1\/CD279 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A11973-20, A11973-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF-P, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 32kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 50kDa\/35kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment)\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5133\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q15116\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; PD-1\/CD279\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:1000 IF-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology Developmental Biology, Apoptosis, Immunology Inflammation, CDs.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: PDCD1\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189510135987,"sku":"A11973-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189510168755,"sku":"A11973-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_0cdd9c65-48f3-4b9f-8c82-4d84ec9032ba.png?v=1766428647","url":"https:\/\/afsbio.com\/products\/pd-1-cd279-rabbit-pab-a11973","provider":"AFSBio Inc.","version":"1.0","type":"link"}