{"product_id":"pd1-monoclonal-antibody-humanized-ap6666","title":"PD1 Monoclonal Antibody (Humanized) - AP6666","description":"\u003cp\u003ePD1 Monoclonal Antibody (Humanized)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: AP6666-50, AP6666-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The humanized monoclonal anti-PD1 antibody can effectively block the combination between PDL1 and PD1, and will not cause HAMA reaction (anti mouse antibody response). Programmed cell death protein 1 (PD-1) (UniProt Q15116), is a type I single transmembrane protein encoded by the PDCD1 gene in human. T-cell activation is generally self-limited as activated T cells express receptors such as PD-1. Maintenance of peripheral tolerance by preventing the development of autoimmunity due to T lymphocytes specific for self-antigens is essential for homeostasis of the immune system. PD-1 can bind two different but related ligands, PDL-1 and PDL-2.PD-1 receptor and its ligands PD-L1 and PD-L2play a vital role in the induction and maintenance of peripheral tolerance. The humanized monoclonal anti-PD1 antibody has demonstrated durable antitumor activity.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: Neutralization\/Block\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PDCD1, PD1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Variable region genes (including VH \u0026amp;VL) of this antibody were derived from a single B cell by PCR.\u003c\/p\u003e \n\n\u003cp\u003eDilution: Neutralization\/Block\u003c\/p\u003e\n\n\u003cp\u003ePurification: Recombinant IgG antibodies were expressed and secreted by 293F cells and purified by Protein A.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PD1 monoclonal antibody (Humanized) detects endogenous levels of human PD1 protein. Variable region genes (including VH \u0026amp;VL) of this antibody were derived from a single B cell by PCR.\u003c\/p\u003e \n\n\u003cp\u003eMolecular Weight: ~ 32 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Immune checkpoint signaling in the Tumor Microenvironment, Tumor-Infiltrating Immune Cell Marker Guide, T cell receptor signaling,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q15116\u003c\/p\u003e\n\n\u003cp\u003eProduct: 1mg\/ml in PBS with 50% Glycerol.\u003c\/p\u003e \n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946184270003,"sku":"AP6666-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946184302771,"sku":"AP6666-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/pd1-monoclonal-antibody-humanized-ap6666","provider":"AFSBio Inc.","version":"1.0","type":"link"}