{"product_id":"pde1a-polyclonal-antibody-bt-ap12868","title":"PDE1A Polyclonal Antibody - BT-AP12868","description":"\u003cp\u003ePDE1A Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP12868-20, BT-AP12868-50, BT-AP12868-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and\/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)\/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PDE1A\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Calcium\/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P54750; Mouse: Q61481\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Calcium\/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A;Cam-PDE 1A;EC 3.1.4.17;61 kDa Cam-PDE;hCam-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5136\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239281909939,"sku":"BT-AP12868-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239281942707,"sku":"BT-AP12868-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239281975475,"sku":"BT-AP12868-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_be78f743-328e-4c2b-b773-84b0a7a6876c.png?v=1769392476","url":"https:\/\/afsbio.com\/products\/pde1a-polyclonal-antibody-bt-ap12868","provider":"AFSBio Inc.","version":"1.0","type":"link"}