{"product_id":"pde4a-polyclonal-antibody-e-ab-92180","title":"PDE4A Polyclonal Antibody - E-AB-92180","description":"\u003cp\u003ePDE4A Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-92180-60, E-AB-92180-120, E-AB-92180-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PDE4A\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: PDE4; DPDE2; PDE46\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P27815\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human PDE4A\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:1000-1:2000, IHC 1:50-1:200, IF 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 98kD\/95kDa\/76kDa\/72kDa\/37kDa\/91kDa\/96kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 80KDa\/110KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146628825267,"sku":"E-AB-92180-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146628858035,"sku":"E-AB-92180-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146628890803,"sku":"E-AB-92180-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_183fcd83-3f37-41be-beef-7e3d8d0dcb49.png?v=1710298807","url":"https:\/\/afsbio.com\/products\/pde4a-polyclonal-antibody-e-ab-92180","provider":"AFSBio Inc.","version":"1.0","type":"link"}