{"product_id":"pde4b-c-d-phospho-ser133-119-190-rabbit-pab-es6524","title":"PDE4B\/C\/D (phospho Ser133\/119\/190) rabbit pAb - ES6524","description":"\u003cp\u003ePDE4B\/C\/D (phospho Ser133\/119\/190) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES6524-50, ES6524-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: PDE4B; DPDE4; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4B; DPDE4; PDE32; PDE4C; DPDE1; cAMP-specific 3', 5'-cyclic phosphodiesterase 4C; DPDE1; PDE21; PDE4D; DPDE3; cAMP-specific 3', 5'-cyclic phosphodiesterase 4D; DPDE3; PDE43\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human PDE4D around the phosphorylation site of Ser190\/53. AA range:156-205\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 76kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 5144\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q07343\/Q08493\/Q08499\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: [Isoform PDE4B5]: Cytoplasm. Cell membrane.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202302075059,"sku":"ES6524-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202302107827,"sku":"ES6524-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_4400a965-b4a8-4c80-b08c-82aedbe586ca.png?v=1767126111","url":"https:\/\/afsbio.com\/products\/pde4b-c-d-phospho-ser133-119-190-rabbit-pab-es6524","provider":"AFSBio Inc.","version":"1.0","type":"link"}