{"product_id":"pdha1-monoclonal-antibody-bt-mca3345","title":"PDHA1 Monoclonal Antibody - BT-MCA3345","description":"\u003cp\u003ePDHA1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3345-50, BT-MCA3345-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction, Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PDHA1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 2A2H7\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2b\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PDHA1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human PDHA1 (AA: 241-390) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 43.3kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P08559\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PDHA, PDHAD, PHE1A, PDHCE1A\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5160\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238517072051,"sku":"BT-MCA3345-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238517104819,"sku":"BT-MCA3345-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_a1c7f043-6bb5-4e72-802f-2c257b48d4d9.png?v=1769382020","url":"https:\/\/afsbio.com\/products\/pdha1-monoclonal-antibody-bt-mca3345","provider":"AFSBio Inc.","version":"1.0","type":"link"}