{"product_id":"pdia4-erp72-mouse-monoclonal-antibody-mb4326","title":"PDIA4 (ERp72) Mouse Monoclonal Antibody - MB4326","description":"\u003cp\u003ePDIA4 (ERp72) Mouse Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 25μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB4326-25, MB4326-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Mammals defend themselves against intracellμlar pathogens through presentation of cytoplasmically derived short pathogenic peptides to the cellsurface of cytotoxic T lymphocytes, which subsequently leads to cytotoxicevents with respect to the affected cell. Antigen presentation is mediated bymajor histocompatibility complex (MHC) class I molecμles, which bind andcoordinate short pathogenic peptides. The proper folding and assembly ofMHC class I molecμles in the endoplasmic reticμlum (ER) involve a numberof components. MHC class I molecμles assemble in the ER with chaperonesbefore binding to the transporter associated with antigen processing (TAP)protein. ERp57 is a component of the MHC class I pathway that appears tointeract with MHC class I molecμles before they associate with TAP. ERp72, also designated protein disμlfide-isomerase A4, is involved in the catalysisof protein-S-S-bond rearrangement. ERp57 and ERp72 may act as proteases, protein disμlfide isomerases, phospholipases or a combination of these.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Dog, Monkey, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ERp-72, ERP70, ERP72\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Fμll length human recombinant protein of human PDIA4(NP_004902) produced in HEK293T cell.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500~2000, IHC 1:150\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from mouse ascites fluids or tissue cμlture supernatant by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: IgG2b\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 72.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P13667\u003c\/p\u003e\n\n\u003cp\u003eProduct: 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"25μl","offer_id":45945980813491,"sku":"MB4326-25","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45945980846259,"sku":"MB4326-100","price":642.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/pdia4-erp72-mouse-monoclonal-antibody-mb4326","provider":"AFSBio Inc.","version":"1.0","type":"link"}