{"product_id":"pdia6-polyclonal-antibody-bs91044","title":"PDIA6 Polyclonal Antibody-BS91044","description":"\u003cp\u003ePDIA6 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91044-50, BS91044-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q15084(Human) Q922R8(Mouse) Q63081(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC\/IF FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000-1:2,000\u003cbr\u003e\nFC:1:50-1:100\u003cbr\u003e\nICC:1:100-1:500\u003c\/p\u003e\n\n\u003cp\u003eBackground: Endoplasmic reticulum proteins (ERps) are widely expressed proteins that localize to the ER and may act as proteases, protein disulfide isomerases, thiol-disulfide oxidases or phospholipases. ERp5, also known as PDIA6 (protein disulfide isomerase family A, member 6) or TXNDC7 is a 440 amino acid protein that contains two thioredoxin domains and belongs to the protein disulfide isomerase family. Localized to the melanosome, as well as to the lumen of the endoplasmic reticulum, ERp5 functions to catalyze the rearrangement of disulfide bonds in a variety of different proteins. Via its catalytic activity, ERp5 is able to reduce the disulfide bond that binds MICA to tumor cells, thereby releasing MICA and reducing the rate of tumor expansion. Multiple isoforms of ERp5 exist due to alternative splicing events.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PDIA6 polyclonal antibody detects endogenous levels of PDIA6 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 48 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of PDIA6 on different lysates using anti-PDIA6 antibody at 1\/1,000 dilution. \u003cbr\u003e\n Positive control: \u003cbr\u003e\n Lane 1: HepG2 \u003cbr\u003e\n Lane 2: K562, ICC staining PDIA6 in Hela cells (red). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: ER protein 5, ERp5, PDIA6, Endoplasmic reticulum protein 5, ER protein 5, ERp5, P5, Pdia6, PDIA6, Protein disulfide isomerase A6, Protein disulfide isomerase associated 6, Protein disulfide isomerase family A member 6, Protein disulfide isomerase P5, Protein disulfide isomerase related protein, Protein disulfide-isomerase A6, Thioredoxin domain containing 7 (protein disulfide isomerase), Thioredoxin domain containing protein 7, Thioredoxin domain-containing protein 7, TXNDC7,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42984609284275,"sku":"BS91044-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42984609317043,"sku":"BS91044-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_4eae509a-8e16-49a9-b2fd-e41d22c14a1d.jpg?v=1705919295","url":"https:\/\/afsbio.com\/products\/pdia6-polyclonal-antibody-bs91044","provider":"AFSBio Inc.","version":"1.0","type":"link"}