{"product_id":"pe-rabbit-anti-human-integrin-β5-itgb5-monoclonal-antibody-a24597","title":"PE Rabbit anti-Human Integrin β5\/ITGB5 Monoclonal Antibody - A24597","description":"\u003cp\u003ePE Rabbit anti-Human Integrin β5\/ITGB5 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A24597-100, A24597-200, A24597-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Ιntegrins, heterodimeric trans-membrane matrix receptors, are mainly involved in the signal transduction and attachments to extra cellular matrix (ECM).†† In ECM they act as a mediator of cell adhesion.† In human, at least 18 α and eight β subunits have been found.† ITGB5 (integrin subunit β 5) helps in facilitation of cancer cell migration, anchorage-independent growth and tumor angiogenesis. Integrin is activated by G-protein-coupled receptors, resulting in the phosphorylation of cytoplasmic domain of the β subunit. The coupled α and β cytoplasmic tails are responsible for maintaining integrin in inactive state.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 88kDa Immunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3693\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P18084\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ITGB5; integrin beta-5\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction, G protein signaling, G2\/M DNA Damage Checkpoint, PI3K-Akt Signaling Pathway, MAPK-Erk Signaling Pathway, Cell Biology and Developmental Biology, Cell Adhesion, Cytoskeleton, Immunology and Inflammation\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: ITGB5\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: PE. Ex:565nm. Em:574nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC60858\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189239767219,"sku":"A24597-100","price":406.0,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189239799987,"sku":"A24597-200","price":672.0,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189239832755,"sku":"A24597-500","price":1075.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_ee53d3e6-f2c5-4e72-bb1d-3c2bc2f1b89e.png?v=1766420108","url":"https:\/\/afsbio.com\/products\/pe-rabbit-anti-human-integrin-%ce%b25-itgb5-monoclonal-antibody-a24597","provider":"AFSBio Inc.","version":"1.0","type":"link"}