{"product_id":"pe-rabbit-anti-human-met-c-met-monoclonal-antibody-a27887","title":"PE Rabbit anti-Human Met\/c-Met Monoclonal Antibody - A27887","description":"\u003cp\u003ePE Rabbit anti-Human Met\/c-Met Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A27887-100, A27887-200, A27887-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC (intra)\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 156kDa Immunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 4233\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P08581\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: DA11; HGFR; AUTS9; RCCP2; c-Met; DFNB97\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC (intra),5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics Nuclear Signaling, Protein phosphorylation, Cancer, Signal Transduction, Kinase, Tyrosine kinases, Cell Biology Developmental Biology, Growth factors, Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: MET\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: PE. Ex:565nm. Em:574nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC74068\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189342036147,"sku":"A27887-100","price":742.0,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189342068915,"sku":"A27887-200","price":1229.2,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189342101683,"sku":"A27887-500","price":1971.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_7132b0a2-77b3-4756-9750-b3e4ec4d60f1.png?v=1766421764","url":"https:\/\/afsbio.com\/products\/pe-rabbit-anti-human-met-c-met-monoclonal-antibody-a27887","provider":"AFSBio Inc.","version":"1.0","type":"link"}