{"product_id":"pe-rabbit-anti-human-stat3-monoclonal-antibody-a28383","title":"PE Rabbit anti-Human STAT3 Monoclonal Antibody - A28383","description":"\u003cp\u003ePE Rabbit anti-Human STAT3 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A28383-100, A28383-200, A28383-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The STAT3 transcription factor is a critical signaling molecule for numerous cytokine and growth factor receptors and is essential for murine fetal development. As an 88 kD member of the STAT (Signal Transducer and Activator of Transcription) protein family, STAT3 is phosphorylated in response to cytokine receptor-associated kinase activity. STAT3 is activated primarily by phosphorylation at Tyr705, which induces its dimerization, nuclear translocation, and DNA binding. STAT3 can form both homodimers and heterodimers and is involved in the activation of genes required for cell growth and the regulation of apoptosis.\u003c\/p\u003e \n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC (intra)\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 88 kDa Immunogen: Synthetic peptide.\u003c\/p\u003e \n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6774\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P40763\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: APRF; HIES; ADMIO; ADMIO1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC,5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics Nuclear Signaling, Transcription Factors, Protein phosphorylation, Cancer, Signal Transduction, ErbB-HER Signaling Pathway, MAPK-Erk Signaling Pathway, MAPK-JNK Signaling Pathway, Cell Biology Developmental Biology, Apoptosis, Inhibition of Apoptosis, Microtubules, Immunology Inflammation, Jak-Stat-IL-6 Receptor Signaling Pathway, Stem Cells, Embryonic Stem Cells, Cardiovascular, Heart, Cardiogenesis, Hypertrophy\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: STAT3\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: PE. Ex:565nm. Em:574nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC70808\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189346951347,"sku":"A28383-100","price":389.2,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189346984115,"sku":"A28383-200","price":683.2,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189347016883,"sku":"A28383-500","price":1537.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_ebef753e-4711-4b29-b896-8e534379da6d.png?v=1766421853","url":"https:\/\/afsbio.com\/products\/pe-rabbit-anti-human-stat3-monoclonal-antibody-a28383","provider":"AFSBio Inc.","version":"1.0","type":"link"}