{"product_id":"pe-rabbit-anti-human-tlr3-monoclonal-antibody-a26593","title":"PE Rabbit anti-Human TLR3 Monoclonal Antibody - A26593","description":"\u003cp\u003ePE Rabbit anti-Human TLR3 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100T, 2 x 100T, 5 x 100T\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A26593-100, A26593-200, A26593-500\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Monoclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplication: FC (intra)\u003c\/p\u003e\n\n\u003cp\u003eCross Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 104kDa Immunogen: Recombinant protein (or fragment).\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 7098\u003c\/p\u003e\n\n\u003cp\u003eSWISS: O15455\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CD283; IIAE2; IMD83\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at 2-8℃. Avoid freeze.|Buffer: PBS with 0.09% Sodium azide,0.2% BSA,pH7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilution: FC (intra),5 μl per 10^6 cells in 100 μl volume\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology;Innate Immunity;Macrophage\/Inflamm\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: TLR3\u003c\/p\u003e\n\n\u003cp\u003eModifications: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: PE. Ex:565nm. Em:574nm.\u003c\/p\u003e\n\n\u003cp\u003eClone Number Info: ARC69609\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"100T","offer_id":45189283545267,"sku":"A26593-100","price":361.2,"currency_code":"CAD","in_stock":true},{"title":"2 x 100T","offer_id":45189283578035,"sku":"A26593-200","price":613.2,"currency_code":"CAD","in_stock":true},{"title":"5 x 100T","offer_id":45189283610803,"sku":"A26593-500","price":1145.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_dbe1ea11-eb98-4017-9761-7cb91467073c.png?v=1766420806","url":"https:\/\/afsbio.com\/products\/pe-rabbit-anti-human-tlr3-monoclonal-antibody-a26593","provider":"AFSBio Inc.","version":"1.0","type":"link"}