{"product_id":"pea-15-rabbit-polyclonal-antibody-es7856","title":"PEA-15 Rabbit Polyclonal Antibody - ES7856","description":"\u003cp\u003ePEA-15 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES7856-50, ES7856-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: phosphoprotein enriched in astrocytes 15(PEA15) Homo sapiens This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Monkey\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: PEA15, Astrocytic phosphoprotein PEA-15, 15 kDa phosphoprotein enriched in astrocytes, Phosphoprotein enriched in diabetes, PED\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human PEA-15. AA range:81-130\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: PEA-15\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PEA-15 Polyclonal Antibody detects endogenous levels of PEA-15 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Ubiquitously expressed, Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source, Lower expression in glucose-producing tissues, Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 36kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface\u003cbr\u003e\nPTM: Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones\u003cbr\u003e\nSimilarity: Contains 1 DED (death effector) domain\u003cbr\u003e\nSubcellular Location: Associated with microtubules\u003cbr\u003e\nSubunit: Binds RPS6KA3, MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD\u003cbr\u003e\nTissue Specificity: Ubiquitously expressed. Mo\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm Associated with microtubules\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: PEA15\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Astrocytic phosphoprotein PEA-15\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 18611\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q62048\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 364052\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q5U318\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313763012787,"sku":"ES7856-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313763045555,"sku":"ES7856-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/pea-15-rabbit-polyclonal-antibody-es7856","provider":"AFSBio Inc.","version":"1.0","type":"link"}