{"product_id":"pebp2β-polyclonal-antibody-ra28664","title":"PEBP2β Polyclonal Antibody - RA28664","description":"\u003cp\u003ePEBP2β Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA28664-50, RA28664-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: core-binding factor beta subunit (CBFB) Homo sapiens The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2\/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2) . The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv (16) (p13q22) ] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11.\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: CBFB; Core-binding factor subunit beta; CBF-beta; Polyomavirus enhancer-binding protein 2 beta subunit; PEA2-beta; PEBP2-beta; SL3-3 enhancer factor 1 subunit beta; SL3\/AKV core-binding factor beta subunit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC-p; IF\/ICC; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 865\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 22\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q13951\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45122357395635,"sku":"RA28664-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45122357428403,"sku":"RA28664-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_3f96ce00-bb53-4e5b-bfd7-c6b4ab8d2bda.png?v=1773347964","url":"https:\/\/afsbio.com\/products\/pebp2%ce%b2-polyclonal-antibody-ra28664","provider":"AFSBio Inc.","version":"1.0","type":"link"}