{"product_id":"peg10-monoclonal-antibody-bt-mca3493","title":"PEG10 Monoclonal Antibody - BT-MCA3493","description":"\u003cp\u003ePEG10 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3493-50, BT-MCA3493-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: PEG10, paternally expressed 10. The PEG10 includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and nuclear signaling, Stem cells, Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PEG10\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 4C10A7\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PEG10\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human PEG10 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): Isoform RF1 (37kDa)|RF1\/RF2 (80kDa)\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q86TG7\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Edr, HB-1, Mar2, MEF3L, Mart2, RGAG3\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 23089\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238643720371,"sku":"BT-MCA3493-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238643753139,"sku":"BT-MCA3493-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_3db4118d-0aaf-4eaa-b25f-b64558a7f643.png?v=1769383350","url":"https:\/\/afsbio.com\/products\/peg10-monoclonal-antibody-bt-mca3493","provider":"AFSBio Inc.","version":"1.0","type":"link"}