{"product_id":"pen2-polyclonal-antibody-bs9960m","title":"PEN2 Polyclonal Antibody-BS9960M","description":"\u003cp\u003ePEN2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS9960M-50, BS9960M-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9NZ42\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC ICC FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500-1:2000   IHC: 1:50-1:200\u003cbr\u003e\nICC: 1:50-1:200        FC: 1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eBackground: Four proteins comprise the gamma-secretase complex: presenilin, nicastrin, aph-1, and PEN-2. Together, these proteins mediate cell surface signaling pathways for a variety of type I membrane proteins, notably amyloid-beta precursor protein, a protein implicated in the development of Alzheimer's disease, via intramembrane proteolysis. The proteins assemble into a proteolytically active complex in the golgi\/trans-golgi network (TGN) compartments. Assembly leads to autocleavage of presenilin into two subunits to create the active site of gamma-secretase, an important step in understanding the mechanisms involved in the etiology and possible treatment of Alzheimer's disease.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Protein A affinity purified.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of PEN2 and does not cross-react with related proteins.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 12 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of PEN2 on mouse spleen tissue lysate using anti-PEN2 antibody at 1:2000 dilution., Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-PEN2 antibody. Counter stained with hematoxylin., Flow cytometric analysis of A549 cells with PEN2 antibody at 1\/100 dilution (purple) compared with an unlabelled control (cells without incubation with primary antibody; yellow). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Gamma-secretase subunit PEN-2; Presenilin enhancer protein 2; PSENEN; PEN2; MDS033\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide corresponding to C-terminal human PEN2.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42987090247859,"sku":"BS9960M-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42987090280627,"sku":"BS9960M-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_3e037279-da8d-43a3-9ecc-89279ac040e5.jpg?v=1706008927","url":"https:\/\/afsbio.com\/products\/pen2-polyclonal-antibody-bs9960m","provider":"AFSBio Inc.","version":"1.0","type":"link"}