{"product_id":"pen2-psenen-polyclonal-antibody-bs76848","title":"PEN2\/PSENEN Polyclonal Antibody-BS76848","description":"PEN2\/PSENEN Polyclonal Antibody\n\nCatalogue Numbers:BS76848-50, BS76848-100\n\nProduct: 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\n\nSwiss-Prot: Q9NZ42\n\nHost: Rabbit\n\nReactivity: Human\n\nApplications: WB\n\nAll Applications: WB,1:500 - 1:2000\n\nBackground: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.\n\nPurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\n\nStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\nSpecificity: Unmodification \n\nNote: For research use only, not for use in diagnostic procedure.\nAlternative Name: PSENEN;MDS033;MSTP064;PEN-2;PEN2\n\nImmunogen: A synthetic peptide of human PEN2\/PEN2\/PSENEN(NP_758844.1).\n\nConjugate: Unconjugated\n\nModification: Unmodified ","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42895108276403,"sku":"BS76848-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42895108309171,"sku":"BS76848-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_5d0b522a-f269-4a90-9888-ff86627a4753.jpg?v=1702573612","url":"https:\/\/afsbio.com\/products\/pen2-psenen-polyclonal-antibody-bs76848","provider":"AFSBio Inc.","version":"1.0","type":"link"}