{"product_id":"pen2-rabbit-polyclonal-antibody-ra28669","title":"PEN2 Rabbit Polyclonal Antibody - RA28669","description":"PEN2 Rabbit Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA28669-50, RA28669-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2) . Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: IHC-p 1：50-200\n\nApplications: IHC-p; IF (paraffin section) \n\nSpecies Cross-Reactivity: Human; Mouse; Rat\n\nGeneID (Human): 55851\n\nSWISS: Q9NZ42\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45119580438707,"sku":"RA28669-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45119580471475,"sku":"RA28669-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d0c0cd87-57ef-45be-913c-6eb61cbdb2fe.png?v=1773354997","url":"https:\/\/afsbio.com\/products\/pen2-rabbit-polyclonal-antibody-ra28669","provider":"AFSBio Inc.","version":"1.0","type":"link"}