{"product_id":"perforin-1-polyclonal-antibody-bt-ap07063","title":"Perforin 1 Polyclonal Antibody - BT-AP07063","description":"\u003cp\u003ePerforin 1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP07063-20, BT-AP07063-50, BT-AP07063-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by PRF1 (perforin 1) has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: Perforin-1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Perforin 1 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 61377\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P14222; Mouse: P10820\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5551; Mouse: 18646\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239825596595,"sku":"BT-AP07063-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239825629363,"sku":"BT-AP07063-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239825662131,"sku":"BT-AP07063-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ec1bc59a-c486-4b92-8d9b-dbb5ace17d3b.png?v=1769399657","url":"https:\/\/afsbio.com\/products\/perforin-1-polyclonal-antibody-bt-ap07063","provider":"AFSBio Inc.","version":"1.0","type":"link"}