{"product_id":"perforin-polyclonal-antibody-e-ab-65660","title":"Perforin Polyclonal Antibody - E-AB-65660","description":"\u003cp\u003ePerforin Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-65660-60, E-AB-65660-120, E-AB-65660-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Perforin\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: PRF1; FLH2; HPLH2; P1; PFN1; PFP; perforin-1; Perforin\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Immunology\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P14222\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human Perforin (NP_001076585.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000   IHC \t1:50-1:200   IF \t1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 61kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 70kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146381983923,"sku":"E-AB-65660-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146382016691,"sku":"E-AB-65660-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146382049459,"sku":"E-AB-65660-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_33edc3e1-5f72-4e5e-a754-ab0580c5f496.png?v=1710294604","url":"https:\/\/afsbio.com\/products\/perforin-polyclonal-antibody-e-ab-65660","provider":"AFSBio Inc.","version":"1.0","type":"link"}