{"product_id":"perk-phospho-thr982-polyclonal-antibody-bs66100","title":"PERK (Phospho-Thr982) Polyclonal Antibody - BS66100","description":"\u003cp\u003ePERK (Phospho-Thr982) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS66100-50, BS66100-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticμlum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: p-PERK(Thr980), PERK(Phospho Thr980), PERK(Phospho T980), HRI, HsPEK, Pancreatic eIF2-alpha kinase, PEK, PRKR like endoplasmic reticμlum kinase, WRS, DKFZp781H1925, EC 2.7.11.1, EIF2AK3, Eukaryotic translation initiation factor 2 alpha kinase 3, Heme regμlated EIF2 alpha kinase\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylated\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PERK.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB\t 1:500 - 1:1000\u003cbr\u003e\nIHC\t 1:100 - 1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PERK (Phospho-Thr980) polyclonal antibody detects endogenous levels of PERK protein only when phosphorylated at Thr980.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 140 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Translational Contral Regμlation of elF2,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q9NZJ5\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946362331315,"sku":"BS66100-50","price":424.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946362364083,"sku":"BS66100-100","price":642.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/perk-phospho-thr982-polyclonal-antibody-bs66100","provider":"AFSBio Inc.","version":"1.0","type":"link"}