{"product_id":"pfkfb3-polyclonal-antibody-e-ab-67803","title":"PFKFB3 Polyclonal Antibody - E-AB-67803","description":"\u003cp\u003ePFKFB3 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-67803-60, E-AB-67803-120, E-AB-67803-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: PFKFB3\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: PFKFB3; IPFK2; PFK2; iPFK-2\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular,Signal Transduction,Neuroscience,Cancer,Metabolism\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q16875\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2, 6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2, 6-bisphosphate (F2, 6BP), and a fructose-2, 6-biphosphatase activity that catalyzes the degradation of F2, 6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human PFKFB3 (NP_004557.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC \t1:50-1:100\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43135896191155,"sku":"E-AB-67803-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43135896223923,"sku":"E-AB-67803-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43135896256691,"sku":"E-AB-67803-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b80b2b9e-d03c-40ca-9233-e5c481f92ff5.png?v=1709986083","url":"https:\/\/afsbio.com\/products\/pfkfb3-polyclonal-antibody-e-ab-67803","provider":"AFSBio Inc.","version":"1.0","type":"link"}