{"product_id":"pgc1α-β-polyclonal-antibody-bs91062","title":"PGC1α\/β Polyclonal Antibody-BS91062","description":"\u003cp\u003ePGC1α\/β Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS91062-50, BS91062-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q86YN6(Human) Q9UBK2(Human) 415302(Mouse) O70343(Mouse) Q8VHJ7(Mouse) Q811R2(Rat) Q9QYK2(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Transcription factors exert their effects by associating with co-activator or corepressor proteins. The co-activator complexes are thought to be constitutively active, requiring only proper positioning in the genome to initiate transcription. Co-activators include the steroid receptor coactivator (SRC) and CREB binding protein (CBP) families that contain histone acetyltransferase (HAT) activity, which modifies chromatin structure. PPARgamma co-activator-1 (PGC-1) is a transcriptional cofactor of nuclear respiratory factor-1 (NRF-1), PPARbeta, PPARalpha and other nuclear receptors that is induced by exposure to cold temperatures and is involved in regulating thermogenic gene expression, protein uncoupling, and mitochondrial biogenesis. PGC-1 has a low inherent transcriptional activity when it is not bound to a transcription factor. Docking of PGC-1 to PPARgamma stimulates an apparent conformational change that then enables PGC-1 to bind to and assemble into complexes, which include the additional cofactors SRC-1 and CBP\/p300, and results in a large increase in transcriptional activity.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of PGC1 alpha+beta on differentLysates using anti-PGC1 alpha+beta antibody at 1\/1,000 dilution. Positive control: Lane 1: Mouse brain Lane 2: Mouse heart Lane 3: Mouse kidney\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 113 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PGC1α\/β polyclonal antibody detects endogenous levels of PGC1α\/β protein.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: PGC-1-alpha, PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, PPARGC1A, PGC-1-beta, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, PPARGC1B, LEM6, Ligand effect modulator 6, PERC, Peroxisome proliferative activated receptor, gamma, coactivator 1 alpha, Peroxisome proliferative activated receptor, gamma, coactivator 1, Peroxisome proliferator activated receptor gamma coactivator 1 alpha, peroxisome proliferator-activated receptor gamma coactivator 1 beta, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, Peroxisome proliferator-activated receptor gamma coactivator 1-beta, peroxisome proliferator-activated receptor gamma, coactivator 1 beta, PGC 1 (alpha), PGC 1 alpha, PGC 1v, PGC-1(beta), PGC-1-alpha, PGC-1-beta, PGC-1-related estrogen receptor alpha coactivator, PGC1, PGC1(alpha), PGC1A, PGC1v, PPAR gamma coactivator 1 alpha, PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6, PPAR gamma coactivator 1, PPAR gamma coactivator variant form, PPAR gamma coactivator-1beta, PPAR-gamma coactivator 1-alpha, PPAR-gamma coactivator 1-beta, PPARGC 1 alpha, PPARGC-1-alpha, PPARGC-1-beta, PPARGC1, PPARGC1A, Ppargc1b, PRGC1, PRGC2,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939205124275,"sku":"BS91062-50","price":415.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939205157043,"sku":"BS91062-100","price":640.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_96d48ecc-cc48-425a-aa11-af8079eb1972.jpg?v=1704545069","url":"https:\/\/afsbio.com\/products\/pgc1%ce%b1-%ce%b2-polyclonal-antibody-bs91062","provider":"AFSBio Inc.","version":"1.0","type":"link"}