{"product_id":"pgi2-synthase-polyclonal-antibody-bt-ap07100","title":"PGI2 synthase Polyclonal Antibody - BT-AP07100","description":"\u003cp\u003ePGI2 synthase Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP07100-20, BT-AP07100-50, BT-AP07100-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: PTGIS (prostaglandin I2 (prostacyclin) synthase) encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PTGIS\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: PGI2 synthase Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 57104\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q16647; Mouse: O35074; Rat: Q62969\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5740; Mouse: 19223; Rat: 25527\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239829233843,"sku":"BT-AP07100-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239829266611,"sku":"BT-AP07100-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239829299379,"sku":"BT-AP07100-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5f70f512-1153-4af2-858f-99ca29fa2cc3.png?v=1769399696","url":"https:\/\/afsbio.com\/products\/pgi2-synthase-polyclonal-antibody-bt-ap07100","provider":"AFSBio Inc.","version":"1.0","type":"link"}