{"product_id":"phf6-rabbit-polyclonal-antibody-es9986","title":"PHF6 Rabbit Polyclonal Antibody - ES9986","description":"\u003cp\u003ePHF6 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES9986-50, ES9986-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms. [provided by RefSeq, Jun 2010],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human protein. at AA range: 290-370\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: PHF6\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: PHF6 Polyclonal Antibody detects endogenous levels of protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000 ELISA 1:5000-20000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Ubiquitously expressed,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 40kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Disease: Defects in PHF6 are the cause of Boerjeson-Forssman-Lehmann syndrome (BFLS) [MIM: 301900], also known as Boerjeson-Forssman syndrome (BORJ). BFLS is a X-linked recessive disorder characterized by moderate to severe mental retardation, epilepsy, hypogonadism, hypometabolism, obesity with marked gynecomastia, swelling of subcutaneous tissue of the face, narrow palpebral fissure and large but not deformed ears\u003cbr\u003e\nFunction: May play a role in transcriptional regulation\u003cbr\u003e\nPTM: Phosphorylated upon DNA damage, probably by ATM or ATR\u003cbr\u003e\nSimilarity: Contains 2 PHD-type zinc fingers\u003cbr\u003e\nSubcellular Location: Nuclear, it particularly localizes to the nucleolus\u003cbr\u003e\nTissue Specificity: Ubiquitously expressed\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Nucleus Nucleus, nucleolus Chromosome, centromere, kinetochore Nuclear, it particularly localizes to the nucleolus\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: PHF6 KIAA1823\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: PHD finger protein 6 (PHD-like zinc finger protein)\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9D4J7\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46314174873779,"sku":"ES9986-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46314174906547,"sku":"ES9986-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/phf6-rabbit-polyclonal-antibody-es9986","provider":"AFSBio Inc.","version":"1.0","type":"link"}