{"product_id":"phospho-14-3-3-theta-tau-s232-polyclonal-antibody-bt-phs00903","title":"Phospho-14-3-3 Theta\/Tau (S232) Polyclonal Antibody - BT-PHS00903","description":"\u003cp\u003ePhospho-14-3-3 Theta\/Tau (S232) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-PHS00903-20, BT-PHS00903-50, BT-PHS00903-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by PLN (phospholamban) is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in PLN are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: YWHAQ\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, mouse, rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Phospho-14-3-3 theta\/Tau (S232) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 27764\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P27348; Mouse: P68254; Rat: P68255\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: YWHAQ; 14-3-3 protein theta; 14-3-3 protein T-cell; 14-3-3 protein tau; Protein HS1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5350; Mouse: 22630; Rat: 25577\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240018632883,"sku":"BT-PHS00903-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240018665651,"sku":"BT-PHS00903-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240018698419,"sku":"BT-PHS00903-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5182cfaa-79f6-40b6-b33f-2240fa90eb6a.png?v=1769402220","url":"https:\/\/afsbio.com\/products\/phospho-14-3-3-theta-tau-s232-polyclonal-antibody-bt-phs00903","provider":"AFSBio Inc.","version":"1.0","type":"link"}