{"product_id":"phospho-20s-proteasomealpha3-s250-polyclonal-antibody-bt-phs00396","title":"Phospho-20S ProteasomeAlpha3 (S250) Polyclonal Antibody - BT-PHS00396","description":"\u003cp\u003ePhospho-20S ProteasomeAlpha3 (S250) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-PHS00396-20, BT-PHS00396-50, BT-PHS00396-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP\/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA3 (proteasome subunit alpha 3) encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: PSMA3\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, mouse, rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Phospho-20S Proteasome alpha3 (S250) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 28433\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P25788; Mouse: O70435; Rat: P18422\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PSMA3; HC8; PSC8; Proteasome subunit alpha type-3; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome component C8\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 5684; Mouse: 19167; Rat: 29670\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240010703027,"sku":"BT-PHS00396-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240010735795,"sku":"BT-PHS00396-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240010768563,"sku":"BT-PHS00396-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_da648680-7e65-406c-b7f0-dc6468c6ff4c.png?v=1769402089","url":"https:\/\/afsbio.com\/products\/phospho-20s-proteasomealpha3-s250-polyclonal-antibody-bt-phs00396","provider":"AFSBio Inc.","version":"1.0","type":"link"}