{"product_id":"phospho-ack-y284-polyclonal-antibody-bt-phs00897","title":"Phospho-ACK (Y284) Polyclonal Antibody - BT-PHS00897","description":"\u003cp\u003ePhospho-ACK (Y284) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-PHS00897-20, BT-PHS00897-50, BT-PHS00897-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: TNK2 encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The tyrosine kinase non receptor 2 may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: TNK2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Phospho-ACK (Y284) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 114327\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q07912; Mouse: O54967\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: TNK2; ACK1; Activated CDC42 kinase 1; ACK-1; Tyrosine kinase non-receptor protein 2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 10188; Mouse: 51789\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240018206899,"sku":"BT-PHS00897-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240018239667,"sku":"BT-PHS00897-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240018272435,"sku":"BT-PHS00897-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_e8fbb531-e6b7-488f-8e16-badac11d697e.png?v=1769402214","url":"https:\/\/afsbio.com\/products\/phospho-ack-y284-polyclonal-antibody-bt-phs00897","provider":"AFSBio Inc.","version":"1.0","type":"link"}