{"product_id":"phospho-akt3-ser472-polyclonal-antibody-bs65910","title":"phospho-AKT3 (Ser472) Polyclonal Antibody - BS65910","description":"\u003cp\u003ephospho-AKT3 (Ser472) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BS65910-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Akt, protein kinase B (PKB), is a serine\/threonine kinase which is involved in many cellμlar signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphtidylinositol 3 kinase (PI 3 kinase). The major activity of Akt\/PKB is to mediate cell survival. Akt\/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI3 kinase and Akt\/PKB kinase activity. There are 3 known isoforms of this enzyme in mammalian cells (1\/alpha, 2\/beta and 3\/gamma). IGF1 leads to the activation of AKT3, which may play a role in regμlating cell survival. It is capable of phosphorylating several known proteins.\u003c\/p\u003e \n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Akt3, AKT3 kinase, AKT3_HUMAN, DKFZp434N0250, PKB gamma, PKBG, PRKBG, Protein kinase Akt-3, Protein Kinase AKT3, Protein kinase B gamma, RAC gamma, RAC gamma serine\/threonine protein kinase, RAC-gamma serine\/threonine-protein kinase, RAC-PK-gamma, RACPK Gamma, Serine threonine protein kinase Akt 3, Serine threonine protein kinase Akt3, STK 2, STK-2, STK2, V akt murine thymoma viral oncogene homolog 3 protein kinase B gamma.\u003c\/p\u003e \n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH conjugated Synthesised phosphopeptide derived from human AKT3 around the phosphorylation site of Ser472:QF(p-S)YS\u003c\/p\u003e \n\n\u003cp\u003eDilution: WB=1:500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: affinity purified by Protein A\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: phospho-AKT3 (Ser472) Polyclonal Antibody detects endogenous levels of AKT3 protein only when phosphorylated at Ser472.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: 56kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Phosphoinosotode Signaling, Immune Cell Signaling, Warburg Effect, Translational Contral elF4 and p70 S6 Kinase, Insμlin \u0026amp;Glucose Signaling, ErbB HER Signaling,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q9Y243\u003c\/p\u003e\n\n\u003cp\u003eProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"100μl","offer_id":45936657858739,"sku":"BS65910-100","price":642.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image.jpg?v=1788296056","url":"https:\/\/afsbio.com\/products\/phospho-akt3-ser472-polyclonal-antibody-bs65910","provider":"AFSBio Inc.","version":"1.0","type":"link"}