{"product_id":"phospho-arrestin-beta-1-s412-polyclonal-antibody-bt-phs00642","title":"Phospho-Arrestin-Beta-1 (S412) Polyclonal Antibody - BT-PHS00642","description":"\u003cp\u003ePhospho-Arrestin-Beta-1 (S412) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-PHS00642-20, BT-PHS00642-50, BT-PHS00642-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Members of arrestin\/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK\/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: ARRB1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, monkey\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Phospho-Arrestin-beta-1 (S412) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 47066\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P49407; Mouse: Q8BWG8\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: ARRB1; ARR1; Beta-arrestin-1; Arrestin beta-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 408\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240014209203,"sku":"BT-PHS00642-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240014241971,"sku":"BT-PHS00642-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240014274739,"sku":"BT-PHS00642-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_1aea495b-e83e-4e9a-81f8-fb26d7de7713.png?v=1769402141","url":"https:\/\/afsbio.com\/products\/phospho-arrestin-beta-1-s412-polyclonal-antibody-bt-phs00642","provider":"AFSBio Inc.","version":"1.0","type":"link"}