{"product_id":"phospho-bcl-x-s62-polyclonal-antibody-bt-phs00034","title":"Phospho-Bcl-x (S62) Polyclonal Antibody - BT-PHS00034","description":"\u003cp\u003ePhospho-Bcl-x (S62) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-PHS00034-20, BT-PHS00034-50, BT-PHS00034-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by BCL2L1 (BCL2 like 1) belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: BCL2L1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, mouse, rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Phospho-Bcl-x (S62) Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 26049\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q07817; Mouse: Q64373; Rat: P53563\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: BCL2L1; BCL2L; BCLX; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 598; Mouse: 12048; Rat: 24888\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240006246579,"sku":"BT-PHS00034-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240006279347,"sku":"BT-PHS00034-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240006312115,"sku":"BT-PHS00034-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_7d90adee-7b47-46f4-90a4-606ebabe9bc5.png?v=1769402036","url":"https:\/\/afsbio.com\/products\/phospho-bcl-x-s62-polyclonal-antibody-bt-phs00034","provider":"AFSBio Inc.","version":"1.0","type":"link"}